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子弹视频 16年專注膽汁酸對脂肪利用和肝腸健康的研究

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高劑量膽汁酸對肉雞生長性能、臨床血液代謝物及器官發育的影響

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掃一掃!高劑量膽汁酸對肉雞生長性能、臨床血液代謝物及器官發育的影響掃一掃!
瀏覽:- 發布日期:2019-08-12 17:14:22【

Bile acids are intended for use in animal feed as a novel feed additive to enhance fat absorption. As far as we know, few studies in avian species have been reported, and a safety study of bile acids has not been done. Therefore, a subchronic broiler chicken safety study was conducted to evaluate whether or not high-dose bile acids could affect the health of broiler chickens. A total of 324 1-day-old Arbor Acres broiler chickens were randomly assigned to 3 treatments with 6 replicates of 18 broiler chickens each. Broiler chickens were fed a corn-soybean meal diet supplemented with 0, 80 (the recommended available dose, RAD), and 400 mg/kg (5-fold of RAD) of bile acids for 42d, respectively. Throughout the study, clinical observation and growth performance were measured. At the end of the study, broiler chickens were subjected to a full postmortem examination: blood samples were collected for clinical pathology, selected organs were weighed, and specified tissues were taken for subsequent histopathological examination. No treatment-related changes considered to be of toxicological significance were observed. Therefore, a nominal bile acids inclusion of 400mg/kg was considered to be the no-observed adverse-effect level.

Key words:broiler chickens, bile acids, safety evaluation, blood parameters, organ development

摘 要:作為一種新型的飼料添加劑,膽汁酸被廣泛應用于飼料中促進脂肪的吸收利用。目前為止,膽汁酸在家禽上的研究報道很少,其安全性也未進行過研究。因此,我們以肉仔雞為研究對象,開展亞慢性安全性研究,以評估高劑量膽汁酸是否會影響其健康。將324只1日齡AA肉雞隨機分為3個處理,每個處理6個重復,每個重復18只。肉雞飼喂玉米-豆粕飼料,分別添加0、80(推薦有效劑量,RAD)和400 mg/kg(5倍推薦有效劑量)膽汁酸,試驗期42天。試驗過程中,對臨床觀察和生長性能進行測定。試驗結束時,屠宰后,對肉雞進行全面的檢驗:采集血液樣品用來進行臨床病理檢驗;對選定的器官稱重;采集特定組織的樣品用來進一步進行組織病理學檢查。沒有觀察到與試驗處理相關的、具有毒理學意義的異樣。因此,膽汁酸添加水平為400 mg/kg時,是不會出現副作用的添加水平。

關鍵詞:肉仔雞;膽汁酸;安全評價;血液指標;器官發育

全文要點:

1、肉雞日糧中添加80 mg/kg膽汁酸,能顯著提高末重和日增重,降低料重比;

子弹视频 2、肉雞日糧中添加80 mg/kg膽汁酸,能顯著降低血清中谷丙轉氨酶(ALT)和谷草轉氨酶(AST)活性,改善肝臟健康;

3、實驗結束時血糖濃度明顯下降,說明高劑量的膽汁酸具有潛在的降糖作用。

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